Estrategia de Ehrlichia Chaffeensis para Evitar el Mecanismo de Defensa Celular en Ehrlichiosis Monocítica Humana

Introduction. There are different vectors in the transmission of diseases in animals and humans; After mosquitoes, ticks are the second vector, which are of concern for public health, due to their morbidity and mortality in humans around the world. For example, monocytic Ehrlichiosis can be suffered by both dogs and humans, transmitted by Ehrlichia canis and Ehrlichia chaffensis is an obligatory intracellular Gram-negative bacteria. These are transmitted by two species of ticks: Rhipicephalus sanguineus, vector of Ehrlichia canis, and Ambyloma americanum for E. Chaffeensis, which causes Human Monocytic Ehrlichiosis, which is an emerging febrile infectious disease transmitted by tick bites and latently fatal. Aim. Describe the disease, transmission mechanism and the main strategy of Ehrlichia chaffeensis to avoid the defense mechanism in leukocytes caused in Human Monocytic Ehrlichiosis. Methodology. Descriptive review through a literature search in various databases Google Scholar, PubMed, SciELO, Redalyc, using the terms “Human Monocytic Ehrlichiosis”, “Ehrlichia Chaffensis”. Results and conclusion. scientific articles were reviewed and consulted, finding the Ehrlichia Chaffensis strategy, distribution, transmission mechanism, pathogenesis, clinical picture and diagnosis of Human Monocytic Ehrlichiosis.Introducción.  Existen diferentes vectores en la transmisión de enfermedades en los animales y el humano; después de los mosquitos, las garrapatas son el segundo vector, los cuales son motivo de preocupación para la salud pública, por su morbilidad y mortalidad en seres humanos alrededor del mundo. Por ejemplo la Ehrlichiosis monocítica la pueden padecer tanto perros como humanos, transmitida por Ehrlichia canis y Ehrlichia chaffensis, es una bacteria Gram negativa obligatoria intracelular. Estas son transmitidas por dos especies de garrapatas: Rhipicephalus sanguineus vector de la Ehrlichia canis y Ambyloma americanum para E.Chaffeensis quien origina Ehrlichiosis Monocítica Humana la cual es una enfermedad infecciosa febril emergente transmitida por la mordedura de garrapatas y latentemente mortal.  Objetivo.  Describir la enfermedad, mecanismo de transmisión y la estrategia principal de Ehrlichia chaffeensis para evitar el mecanismo de defensa en leucocitos causado en Ehrlichiosis Monocítica Humana.  Metodología: Revisión descriptiva por medio de una búsqueda en la literatura en diversas bases de datos Google Académico, PubMed, SciELO, Redalyc, utilizando los términos “Ehrlichiosis Monocitica Humana”, “Ehrlichia Chaffensis”.  Resultados y conclusión: se revisaron y consultaron artículos científicos, encontrando la estrategia de Ehrlichia Chaffensis, distribución, mecanismo de transmisión, patogenia, cuadro clínico y diagnóstico de la Ehrlichiosis Monocitica Humana

Burnout Docente, sentido de la coherencia y salud percibida

The present study was proposed as a revision about the burnout process. The incidence of the organizational factors in development of burnout was analyzed, as well as it relationship to perceived health reports. Assumption of sense of coherence (SC) as a mediator in the process was analyzed. Data were collected from 115 Primary School teachers using the CBP, the OLQ, and a symptomatology questionnaire which one collects information about physical and psychological symptoms. Regression analysis identified work environment stressors on the basis of the burnout syndrome. It was notable the relationship between role stress and teacher burnout, specifically by means of the emotional exhaustion dimension of burnout. Both (role stress and emotional exhaustion), were strong predictors of reported health problems. Moreover, sense of coherence (SC) was identified as an important mediator in the process, especially by means of it three composing dimensions.El presente trabajo se propone una revisión del proceso de burnout, analizando la incidencia de los factores organizacionales en el desarrollo del síndrome, así como su asociación con la salud percibida. Se presta especial atención al supuesto papel mediador que desempeña en el proceso la variable de personalidad denominada sentido de coherencia (SC). La muestra utilizada la componen 115 profesores de Educación Primaria que respondieron a los ítems del CBP, del OLQ, y a un cuestionario de sintomatología que recoge manifestaciones autoinformadas tanto de carácter físico como psicológico. El análisis de regresión efectuado muestra la importancia en el desarrollo del burnout de las fuentes potenciales de estrés propias de la organización en la que el profesor desempeña su trabajo. Es especialmente notable la asociación del estrés de rol con el burnout, especialmente con la dimensión de agotamiento emocional, y de ambos con los problemas de salud autoinformados. Además, el estudio hace patente el importante papel mediador que ejerce el sentido de coherencia (SC) en el proceso, especialmente si se consideran de forma específica las dimensiones que componen este constructo

Clinical Efficacy and Safety of Fanhdi^®, a Plasma-Derived VWF/Factor VIII Concentrate, in von Willebrand Disease in Spain: A Retrospective Study

Objective: To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients. Methods: A retrospective, multicentric, observational study of VWD patients treated with Fanhdi®, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis. Results: Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed. Conclusions: Fanhdi® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patientsThe author(s) disclosed receipt of the followingfinancial support forthe research, authorship, and/or publication of this article: This workwas supported by Grifols, manufacturer of the pdVWF/FVIII,Fanhdi

Clinical Efficacy and Safety of Fanhdi ®, a Plasma-Derived VWF/Factor VIII Concentrate, in von Willebrand Disease in Spain : A Retrospective Study

UDHEBRONTo evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients. A retrospective, multicentric, observational study of VWD patients treated with Fanhdi ®, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis. Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed. Fanhdi ® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patients

Epidemiologic Features and Control Measures during Monkeypox Outbreak, Spain, June 2022

During June 2022, Spain was one of the countries most affected worldwide by a multicountry monkeypox outbreak with chains of transmission without identified links to disease-endemic countries. We provide epidemiologic features of cases reported in Spain and the coordinated measures taken to respond to this outbreak.S

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection